10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine → HCID 10199923, compound

HRID 1793976Notes

Reaction equation

HRID 1793976 reaction equation
[CH3:1][C:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]=1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=1.[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[NH:23][CH2:22][C:21]=12>>[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[N:23]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([C:3]4[CH2:4][CH2:5][CH2:6][CH2:7][C:2]=4[CH3:1])=[CH:16][CH:15]=3)=[O:14])[CH2:22][C:21]=12

Participants

3

Reactant 2

HCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepineHCID 22219711HCID 22219711, compound

Product 1

HCID 10199923HCID 10199923, compoundYield 91.9%

Procedure

4-(2-Methyl-cyclohex-1-en-1-yl)-benzoic acid of Step C (0.720 g, 3.33 mmol) and 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine (0.674 g, 3.66 mmol) were reacted in the manner of Example 1, Step D. The title compound was purified by recrystallization from petroleum ether to afford white crystals (1.17 g), m.p. 119–120° C.

Workup

  1. customThe title compound was purified by recrystallization from petroleum ether

Sources & evidence

ORD record
ord-53c78aa057af4a4e957fe1adb616dcab
Source dataset
uspto-grants-2006_04
Patent number
US07022699B2

Reaction notes

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