10,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine → HCID 10156754, compound

HRID 1793986Notes

Reaction equation

HRID 1793986 reaction equation
[CH3:1][CH:2]1[C:7]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=O)=[CH:10][CH:9]=2)=[CH:6][CH2:5][CH2:4][CH2:3]1.[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[NH:23][CH2:22][C:21]=12>>[CH:17]1[CH:18]=[CH:19][N:20]2[CH2:26][C:25]3[CH:27]=[CH:28][CH:29]=[CH:30][C:24]=3[N:23]([C:12]([C:11]3[CH:10]=[CH:9][C:8]([C:7]4[CH:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH:6]=4)=[CH:16][CH:15]=3)=[O:14])[CH2:22][C:21]=12

Participants

3

Reactant 2

HCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepineHCID 22219708HCID 22219708, compound

Product 1

HCID 10156754HCID 10156754, compoundYield 96.8%

Procedure

4-(6-Methyl-cyclohex-1-en-1-yl)-benzoic acid of Step B (0.070 g, 0.324 mmol) and 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine (0.066 g, 0.356 mmol) were reacted in the manner of Example 15, Step D. The title compound was purified by recrystallization from a mixture of diethyl ether and petroleum ether to afford 0.120 g of white crystals, m.p. 108–109° C.

Workup

  1. customThe title compound was purified by recrystallization from a mixture of diethyl ether and petroleum ether

Sources & evidence

ORD record
ord-342b1c2b58ee4a37b20c429ca2c4f1b3
Source dataset
uspto-grants-2006_04
Patent number
US07022699B2

Reaction notes

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