反应详情

4-(Tri-n-butyl-stannyl)-benzoic acid ethyl ester of Example 15, Step A (2.58 g, 5.88 mmol) and 3,4-dihydro-naphthalen-1-yl trifluoromethanesulfonate (1.80 g, 6.47 mmol) were reacted in the manner of Example 15, Step B. Purification by flash column chromatography on silica gel, eluting with a solvent gradient of from 0 to 10% ethyl acetate in hexane followed by recrystallization from pentane (−20° C.) afforded the title compound (1.53 g) as slightly yellow crystals, m.p. 81° C.

1. customPurification by flash column chromatography on silica gel
2. washeluting with a solvent gradient of from 0 to 10% ethyl acetate in hexane
3. customfollowed by recrystallization from pentane (−20° C.)