HCID 10157588, compound → (10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-[4-(3-hydroxy-cyclohex-1-en-1-yl)-3-methyl-phenyl]-methanone

HRID 1794019Notes

Reaction equation

HRID 1794019 reaction equation
[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4[CH2:28][CH2:27][CH2:26][C:25](=[O:29])[CH:24]=4)=[C:19]([CH3:30])[CH:18]=3)=[O:16])[CH2:6][C:5]=12>C(OCC)C>[CH:1]1[CH:2]=[CH:3][N:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[N:7]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([C:23]4[CH2:28][CH2:27][CH2:26][CH:25]([OH:29])[CH:24]=4)=[C:19]([CH3:30])[CH:18]=3)=[O:16])[CH2:6][C:5]=12

Participants

3

Reactant 1

HCID 10157588HCID 10157588, compound

Product 1

HCID 10294306(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-[4-(3-hydroxy-cyclohex-1-en-1-yl)-3-methyl-phenyl]-methanoneYield 99.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-[4-(10,11-Dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine-10-carbonyl)-2-methyl-phenyl]-cyclohex-2-enone of Example 39 (0.100 g, 0.252 mmol) was reacted in the manner of Example 25. The crude product was dissolved in boiling diethyl ether, filtered and the product precipitated from the filtrate by addition of pentane to provide the title compound (0.100 g) as a white solid.

Workup

  1. filtrationfiltered
  2. customthe product precipitated from the filtrate by addition of pentane

Sources & evidence

ORD record
ord-66e7f864830d407dbf6eca9647f5b6c5
Source dataset
uspto-grants-2006_04
Patent number
US07022699B2

Reaction notes

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