Phenacyl bromide → HCID 22220812, compound

Participants

Reaction Steps

1-(2-Thiazolyl)ethanol (0.71 g, 5.49 mmole), 2-bromo-1-phenyl-1-ethanone (1.09 g, 5.47 mmole), and acetonitrile (0.6 mL) were combined and heated with stirring at 130 C for 4 hr. After cooling, water (20 mL) was added and the mixture was filtered and extracted twice with ether. The aqueous layer was treated with active carbon and filtered to give a clear solution which was concentrated in vacuo to 1.52 g of residue, which was crystallized from acetonitrile/ether and recrystallized twice from methanol/acetonitrile/ether to give 0.77 g of the title compound as prisms, mp 157–158 C; calc'd for C13H)4NO2SBr: C, 47.55; H, 4.33; N, 4.26; found: C, 47.52; H, 4.32; N, 4.14.

Provenance & Evidence