Phenacyl bromide → 2,4-Dimethyl-3-(2-oxo-2-phenylethyl)-1,3-thiazol-3-ium bromide

Participants

Reaction Steps

2,4-Dimethylthiazole (0.5 g, 4.41 mmole), 2-bromo-1-phenyl-1-ethanone (0.879 g, 4.41 mmole), and acetonitrile (0.25 mL) were heated in an oil bath at 105 C for 1.5 hr. Product precipitation began within 10 min. After cooling, acetonitrile (5 mL) and ether (4 mL) were added and the mixture stood at room temp. overnight. Filtration and washing with 30% ether/acetonitrile gave 1.2 g crude product which was recrystalized from methanol/acetonitrile/ether to afford 0.97 g of the title compound, mp 235–237 C (dec.).

Provenance & Evidence