Diethyl Ether → HCID 22220766, compound

Participants

Reaction Steps

2-Pyridineacetonitrile (0.8 g, 6.77 mmole) and 1-(bromoacetyl)pyrrolidine (1.3 g, 6.77 mmole) were warmed to melt the 1-(bromoacetyl)pyrrolidine, then stirred at room temp. for 3 days. The mixture was dissolved in acetonitrile (5 mL) and ether (2 mL) and stored at 4 C for 3 days. The crystals which separated were filtered out to yield a crude product which was dissolved in methanol, decolorized, evaporated, and the residue triturated with 30% ether-acetonitrile to obtain 0.72 g of the title compound, mp 150–152 C.

Provenance & Evidence