1-Chloro-4-(chloromethyl)benzene → HCID 69141647, compound

HRID 1794065Notes

Reaction equation

HRID 1794065 reaction equation
[C:1]([N:8]1[C@H:13]([CH3:14])[CH2:12][NH:11][CH2:10][C@@H:9]1[CH3:15])([O:3][C:4]([CH3:7])(C)C)=[O:2].[Cl:16][C:17]1[CH:24]=[CH:23]C(CCl)=[CH:19][CH:18]=1>>[ClH:16].[Cl:16][C:17]1[CH:24]=[CH:23][C:7]([CH2:4][O:3][C:1]([N:8]2[C@H:9]([CH3:15])[CH2:10][NH:11][CH2:12][C@@H:13]2[CH3:14])=[O:2])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 77231-Chloro-4-(chloromethyl)benzeneHCID 21021901tert-Butyl (2R,6S)-2,6-dimethylpiperazine-1-carboxylate

Product 1

HCID 69141647HCID 69141647, compound

Procedure

Prepared in analogy to Example 25 with cis-N-Boc-2,6-dimethyl-piperazine and 4-chloro-benzyl chloride. Colourless powder, 1H-NMR (d6-DMSO): 1.30 d 7.2 Hz, 6H; 3.0–3.25 m, 4H and 4.2–4.4 m, 2H; 5.11 s, 2H; 7.35–7.55 AB-system, 4H; 9.5 br, 2H. MS (ISP): 283.1 (M+H)+.

Workup

  1. custom5.11 s, 2H

Sources & evidence

ORD record
ord-11d0704c307b44d2ba28abcf9b2b1086
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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