Water → HCID 69142608, compound

Participants

Reaction Steps

A solution of 274 mg (0.5 mmol) piperazine-1,4-dicarboxylic acid 4-benzyloxy-benzyl ester 9H-fluoren-9-ylmethyl ester in 13 ml morpholine was stirred at rt for 1 h. Then 23 ml of chilled water was added, the suspension filtered and the filtrate extracted with TBME. The organic layer was washed with water, brine, dried over Na2SO4 and evaporated: 54 mg piperazine-1-carboxylic acid 4-benzyloxy-benzyl ester as light yellow, waxy solid. MIR: 3300 cm−1, 1688 cm−1. 1H-NMR (CDCl3): 1.77 br, 1H; 2.75–2.90 m, 4H and 3.40–3.50 m, 4H; 5.06 s and 5.07 s, 4H; 6.96 d, J=8.8 Hz, 2H and 7.28–7.44 m, 7H. MS (ISP): 327.3 (M+H)+.

Provenance & Evidence