Hydrochloric Acid → HCID 69142710, compound

Participants

Reaction Steps

4M HCl in 1,4-dioxane (2.3 mL, 9.2 mmol) was added to a solution of piperazine-1,4-dicarboxylic acid 3-(2-phenylethoxy)benzyl ester tert-butyl ester (0.10 g, 0.23 mmol) in methanol (2 mL) and ether (2 mL) and the solution was left to stand with occasional swirling at room temperature for 3 h. The solution was concentrated in vacuo and the residue was triturated with ether to yield the title compound (0.08 g, 93%) as a white solid. 1H-NMR (400 MHz, d6-DMSO): 3.03 (2H, t, J=6.8 Hz), 3.08 (4H, m), 3.61 (4H, m), 4.19 (2H, t, J=7.0 Hz), 5.06 (2H, s), 6.88–6.94 (3H, m), 7.20–7.33 (6H, m) and 9.19 (2H, br s).

Provenance & Evidence