(4-Bromo-2-fluorophenyl)methanol → 4-Bromo-2-fluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

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Reaction Steps

4-Bromo-2-fluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was synthesized from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 4-bromo-2-fluorobenzyl alcohol according to the methods described in Examples 52 and 54 to give the product as a white solid: δH (400 MHz, DMSO-d6) 1.3 (6H, d J, 7.2 Hz), 3.0–3.2 (4H, m), 4.3 (2H, sextet, J 7.2 Hz), 5.15 (2H, s), 7.42 (2H, m), 7.6 (1H, m), 9.15 (1H, br) and 9.80 (1H, br); LC (XTERRA, 50/80, 220 nm) 89.8% (3.62 min).

Provenance & Evidence