Benzyl Alcohol → Benzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

Participants

Reaction Steps

Benzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and benzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a cream solid (0.0833 g, 15% overall); νmax (nujol)/cm−1 2776, 2672, 2568, 2527, 1706, 1581, 1415, and 1329; δH (400 MHz, DMSO-d6) 9.89 (1 H, br), 9.19 (1 H, br), 7.41–7.31 (5H, m), 5.13 (2 H, s), 4.34 (2 H, m), 3.17–3.08 (4 H, m), and 1.31 (6 H, d, J 7.2).

Provenance & Evidence