2-Chlorobenzyl alcohol → 2-Chlorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

Participants

Reaction Steps

2-Chlorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2-chloro-benzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a white solid (0.0901 g, 14% overall); νmax (nujol)/cm−1 3375, 2689, 2577, 1699, 1592, 1380, 1328, and 1300; δH (400 MHz, DMSO-d6) 9.62 (2 H, br), 7.50 (2 H, m), 7.40 (2 H, m), 5.19 (2 H, s), 4.33 (2 H, m), 3.18–3.06 (4 H, m), and 1.31 (6 H, d, J 7.2).

Provenance & Evidence