2,3-Difluorobenzyl Alcohol → 2,3-Difluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

Participants

Reaction Steps

2,3-Difluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2,3-difluorobenzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a white solid (0.1846 g, 57% overall); (Found: C, 52.4; H, 6.0; N, 8.6%. C14H18F2N2O2.HCl requires C, 52.4; H, 6.0; N, 8.7%); δH (400 MHz, DMSO-d6) 10.07 (1H, br), 9.33 (1H, br), 7.44 (1H, m), 7.28 (2H, m), 5.21 (2H, s), 4.30 (2H, m), 3.14 (2H, d, J 13.2 Hz), 3.06 (2H, m), and 1.31 (6 H, d, J 7.2 Hz).

Provenance & Evidence