Benzenemethanol, 4-(difluoromethoxy)-2,6-difluoro- → 2,6-Difluoro-4-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride

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Reaction Steps

2,6-Difluoro-4-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 2,6-difluoro-4-difluoromethoxybenzyl alcohol according to the method described for Example 54 to give the product as a, white solid (0.1406 g, 65% overall); νmax (nujol)/cm−1 3342, 1684, 1640, 1599, 1378, 1308, 1166, and 1089; δH (400 MHz, DMSO-d6) 9.69 (2H, br), 7.38 (1H, t, J 73 Hz), 7.15–7.10 (2H, m), 5.14 (2H, s), 4.24 (2H, m), 3.13 (2H, d, J 13 Hz), 3.05 (2H, dd, J 5.2 and 13 Hz), and 1.27 (6H, d, J 7.2 Hz).

Provenance & Evidence