4-Methylbenzyl alcohol → HCID 69141378, compound

Participants

Reaction Steps

4-Methylbenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine and 4-methylbenzyl alcohol according to the methods described for Examples 52 and 54 to give the product as a white solid (0.2614 g, 87% overall); λmax (diffuse reflectance)/cm−1 2749, 2656, 2541, 1697, 1594, 1518, 1330, and 1112; δH (400 MHz, DMSO-d6) 10.05 (1H, br), 9.32 (1H, br), 7.26 (2H, d, J 8.0 Hz), 7.18 (2H, d, J 8.0 Hz), 5.07 (2H, s), 4.30 (2H, m), 3.14 (2H, d, J 12.8 Hz), 3.05 (2H, m), 2.30 (3H, s), and 1.30 (6H, d, J 7.2 Hz).

Provenance & Evidence