HCID 69142236, compound → HCID 69141497, compound

Participants

Reaction Steps

2-Fluoro-5-difluoromethoxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from 2-fluoro-5-difluoromethoxybenzyl alcohol and cis 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (0.1473 g, 84%); νmax (diffuse reflectance)/cm−1 2780, 2314, 1697, 1593, 1501, 1327, 1209, and 1101; δH (400 MHz, DMSO-d6) 9.74 (1H, br), 9.18 (1H, br), 7.35–7.22 (3H, m), 7.20 (1H, t, J 74 Hz), 5.17 (2H, s), 4.31 (2H, m, J 6.4 Hz), 3.16 (2H, d, J 13 Hz), 3.08 (2H, dd, J 5.2 and 13 Hz), and 1.30 (6H, d, J 7.2 Hz).

Provenance & Evidence