1-Iodopropane → (R)-2-Fluoro-5-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate

Participants

Reaction Steps

(R)-2-Fluoro-5-propoxybenzyl 2-methylpiperazine-1-carboxylate fumarate was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 1-iodopropane and (R) 1-chlorocarbonyl-2-methyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 54 and 96 to give the product as a white solid (26.4%); melting point 162.6–162.7° C.; NMR δH (400 MHz, DMSO-d6) 0.963(3H, t, J 7.5 Hz), 1.173(3H, d, J 7.0 Hz), 1.709(2H, m), 2.582(1H, m), 2.801(2H, bs), 2.991(2H, bm), 3.731(1H, bdd), 3.895(2H, t, J 6.5 Hz), 4.142(1H, bm), 5.077(2H,q), 6.556(2H, s), 6.931(2H, m) and 7.126(1H, t, J 9.0 Hz).

Provenance & Evidence