2-Chloro-6-fluorobenzyl alcohol → HCID 69143880, compound

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Reaction Steps

2-Chloro-6-fluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from 2-chloro-6-fluorobenzyl alcohol and 1-chlorocarbonyl-cis-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (0.2713 g, 80% overall); (Found: C, 49.8; H, 5.7; N, 8.0%. C14H18ClN2O2.HCl requires C, 49.9; H, 5.7; N, 8.3%); δH (400 MHz, DMSO-d6) 10.01 (1H, br), 9.27 (1H, br), 7.49 (1H, m, J 8.0 Hz), 7.40 (1H, d, J 8.0 Hz), 7.30 (1H, t, J 9 Hz), 5.22 (2H, d, J 1.6 Hz), 4.24 (2H, m, J 6.5 Hz), 3.17–3.06 (4H, m), and 1.28 (6H, d, J 7.2 Hz).

Provenance & Evidence