1-(Chloromethyl)-4-(difluoromethoxy)benzene → HCID 69142885, Verbindung

HRID 1794122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1794122
[F:1][C:2]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][C:3]=1[CH2:4][OH:5].[F:11][CH:12]([F:22])[O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][Cl:19])=[CH:16][CH:15]=1.Cl[C:24]([N:26]1[CH:31]([CH3:32])[CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH:27]1[CH3:40])=[O:25]>>[ClH:19].[CH3:40][C@H:27]1[CH2:28][NH:29][CH2:30][C@@H:31]([CH3:32])[N:26]1[C:24]([O:5][CH2:4][C:3]1[CH:6]=[C:7]([O:10][CH2:18][C:17]2[CH:20]=[CH:21][C:14]([O:13][CH:12]([F:22])[F:11])=[CH:15][CH:16]=2)[CH:8]=[CH:9][C:2]=1[F:1])=[O:25]

Komponenten

4

Edukt 3

HCID 146742741-(Chloromethyl)-4-(difluoromethoxy)benzeneHCID 22219933rac-tert-butyl (3R,5S)-4-(carboxy)-3,5-dimethylpiperazine-1-carboxylateHCID 691416144-Fluoro-3-(hydroxymethyl)phenol

Produkt 1

HCID 69142885HCID 69142885, Verbindung

Versuchsvorschrift

2-Fluoro-5-(4-difluoromethoxybenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate hydrochloride was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 4-difluoromethoxybenzyl chloride and 1-chlorocarbonyl-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the methods described for Examples 52 and 54 to give the product as a white solid (0.224 g, 94% overall); (Found: C, 55.7; H, 5.7; N, 5.9. C22H25F3N2O4.HCl requires C, 55.6; H, 5.5; N, 5.9%); δH (400 MHz, DMSO-d6) 9.8 (1H, br), 9.3 (1H, br), 7.50 (2H, d, J 8.4 Hz), 7.26(1H, t, J 74 Hz), 7.21–7.15 (3H, m), 7.09 (1H, m), 7.03 (1H, m, J 3.2 Hz), 5.12 (2H, s), 5.08 (2H, s), 4.28 (2H, m, J 6 Hz), 3.15 (2H, d, J 13 Hz), 3.06 (2H, dd, J 5 and 13 Hz), and 1.29 (6H, d, J 7.2 Hz).

Quellen und Nachweise

ORD-Eintrag
ord-7b5739f252044bceb59b5168bfeba36b
Quelldatensatz
uspto-grants-2006_04
Patentnummer
US07022707B2

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