(5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol → HCID 69595763, compound

Participants

Reaction Steps

cis-2,6-Dimethyl-piperazine-1-carboxylic acid 2,6-difluoro-4-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-benzyl ester was prepared from 2,6-difluoro-4-hydroxybenzyl alcohol, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol and 1-chlorocarbonyl-cis-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the procedures described for Example 54 and 121 to give the product as a yellow oil: δH (400 MHz; d6-DMSO) 1.15 (6H, d, J 7.0 Hz), 2.53 (3H, s), 2.62 (2H, dd, J 12.0, 4.5 Hz), 2.68 (2H, d, J 12.0 Hz), 3.80–3.88 (2H, m), 5.01–5.08 (4H, m), 6.84–6.91 (2H, m), 7.48–7.53 (3H, m) and 7.64–7.68 (2H, m).

Provenance & Evidence