HuagongsheHuagongshe Chemistry Print Report · For research reference only
187154-69-4 → HCID 69141782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 187154-69-4 | HCID 11084549 | — |
| Reactant | 4-Fluoro-3-(hydroxymethyl)phenol | HCID 69141614 | — |
| Reactant | rel-1,1-Dimethylethyl (3R,5S)-4-(chlorocarbonyl)-3,5-dimethyl-1-piperazinecarboxylate | HCID 86585999 | — |
| Product | HCID 69141782 | HCID 69141782 | — |
Reaction Steps
5-(5-[2,1,3]Benzothiadiazolylmethyl)oxy-2-fluorobenzyl cis-2,6-dimethylpiperazine-1-carboxylate was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 5-[2,1,3]benzothiadiazolylmethyl chloride and 1-chlorocarbonyl-cis-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the procedures described for Examples 121 and 54 to give the product as a yellow oil: δH (400 MHz, DMSO-d6) 1.25 (6H, d, J 7.0 Hz), 2.78–2.95 (4H, m), 4.10 (2H, br), 5.20 (2H, s), 5.22 (2H, s), 6.90–7.08 (3H, m), 7.65 (1H, m) and 8.03 (2H, m), NH not observed; HPLC (XTERRA, 50/80%, 220 nm) 90.7% (4.84 min).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022707B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-6c634d67cac142a8a0aff0042bc2112a |
| Source note | uspto-grants-2006_04 |