3-Fluorobenzyl bromide → HCID 69141024, compound

Participants

Reaction Steps

2-Fluoro-5-(3-fluorobenzyl)oxybenzyl cis-2,6-dimethylpiperazine-1-carboxylate was prepared from 2-fluoro-5-hydroxybenzyl alcohol, 3-fluorobenzyl bromide and 1-chlorocarbonyl-cis-2,6-dimethyl-4-tert-butoxycarbonylpiperazine according to the procedures described for Examples 121 and 54 to give the product as a yellow oil: δH (400 MHz, DMSO-d6) 1.28 (6H, d, J 6.9 Hz), 2.77–2.90 (4H, m), 4.10 (2H, br), 5.03 (2H, s), 5.17 (2H, s), 6.85 (1H, m), 6.95–7.10 (3H, m), 7.15 (2H, m) and 7.35 (1H, m), NH not observed; HPLC (XTERRA, 50/80%, 220 nm) 85% (4.83 min).

Provenance & Evidence