HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Bromo-2,6-difluorophenyl)methanol → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(3-bromo-2,6-difluoro-benzyl) ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Bromo-2,6-difluorophenyl)methanol | HCID 22219889 | — |
| Reactant | (R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86586001 | — |
| Product | (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(3-bromo-2,6-difluoro-benzyl) ester | HCID 69141503 | — |
Reaction Steps
The compound was prepared from (3-bromo-2,6-difluoro-phenyl)-methanol and (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedures described in Example 121 and 54 to give the product as a colorless oil (9.22 g); MS (ISP): 480.3, 482.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022707B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-7d2836a97a074568a47ca6f1d41ddaea |
| Source note | uspto-grants-2006_04 |