HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Ethoxy-2,6-difluorophenyl)methanol → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(4-ethoxy-2,6-difluoro-benzyl) ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Ethoxy-2,6-difluorophenyl)methanol | HCID 22219845 | — |
| Reactant | (R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86586001 | — |
| Product | (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(4-ethoxy-2,6-difluoro-benzyl) ester | HCID 69142692 | 81% |
Reaction Steps
This compound was prepared from 4-ethoxy-2,6-difluoro-benzylalcohol and (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedure described in Example 179 to give the product as a colorless oil (478 mg; 81%); MS (ISP): 429.6 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022707B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-8b2ddae080a943f0a70377ef2094eed0 |
| Source note | uspto-grants-2006_04 |