1-Bromopropane → 2-Chloro-6-fluoro-4-propoxy-benzylalcohol

HRID 1794158Notes

Reaction equation

HRID 1794158 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:11])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9].[CH2:12](Br)[CH2:13][CH3:14]>>[Cl:1][C:2]1[CH:3]=[C:4]([O:11][CH2:12][CH2:13][CH3:14])[CH:5]=[C:6]([F:10])[C:7]=1[CH2:8][OH:9]

Participants

3

Reactant 2

HCID 78401-BromopropaneHCID 222200093-Chloro-5-fluoro-4-(hydroxymethyl)phenol

Product 1

HCID 222200342-Chloro-6-fluoro-4-propoxy-benzylalcoholYield 69%

Procedure

This compound was prepared from 3-Chloro-5-fluoro-4-hydroxymethyl-phenol and propylbromide according to the procedure described in Example 179 to give the product as a yellowish oil (259 mg, 69%); MS (EI): 218.1 (M)+.

Sources & evidence

ORD record
ord-8ba868f8997c4c898dd007709d04531d
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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