HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-6-fluoro-4-(3-methoxy-propoxy)-benzylalcohol → (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-chloro-6-fluoro-4-(3-methoxy-propoxy)-benzyl)ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-6-fluoro-4-(3-methoxy-propoxy)-benzylalcohol | HCID 22219994 | — |
| Reactant | (R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester | HCID 86586001 | — |
| Product | (R)-2-Ethyl-piperazine-1,4-dicarboxylic acid 4-tert-butyl ester 1-(2-chloro-6-fluoro-4-(3-methoxy-propoxy)-benzyl)ester | HCID 69142045 | 77% |
Reaction Steps
This compound was prepared from 2-chloro-6-fluoro-4-(3-methoxy-propoxy)-benzylalcohol and (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedure described in Example 179 to give the product as a colorless oil (576 mg; 77%); MS (ISP): 506.4 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022707B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-ce55d3f28d66413285bd6d6a4376bdc8 |
| Source note | uspto-grants-2006_04 |