HCID 22219897, compound → HCID 69141522, compound

HRID 1794169Notes

Reaction equation

HRID 1794169 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[N:13]=[C:14]([CH3:17])[S:15][CH:16]=2)[CH:7]=[C:6]([F:18])[C:3]=1[CH2:4][OH:5].[C:19]([O:23][C:24]([N:26]1[CH2:31][CH2:30][N:29]([C:32](Cl)=[O:33])[C@H:28]([CH2:35][CH3:36])[CH2:27]1)=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[N:13]=[C:14]([CH3:17])[S:15][CH:16]=2)[CH:7]=[C:6]([F:18])[C:3]=1[CH2:4][O:5][C:32]([N:29]1[CH2:30][CH2:31][N:26]([C:24]([O:23][C:19]([CH3:21])([CH3:20])[CH3:22])=[O:25])[CH2:27][C@H:28]1[CH2:35][CH3:36])=[O:33]

Participants

3

Reactant 2

HCID 22219897HCID 22219897, compoundHCID 86586001(R)-4-Chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 69141522HCID 69141522, compoundYield 75%

Procedure

This compound was prepared from 2-chloro-6-fluoro-4-(2-methyl-thiazol-4-ylmethoxy)-benzylalcohol and (R)-4-chlorocarbonyl-3-ethyl-piperazine-1-carboxylic acid tert-butyl ester according to the procedure described in Example 179 to give the product as a colorless oil (582 mg; 75%); MS (ISP): 528.2 (M+H)+.

Sources & evidence

ORD record
ord-e3265050ae604554b05345e117f5da27
Source dataset
uspto-grants-2006_04
Patent number
US07022707B2

Reaction notes

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