1-(3,5-Dichloropyridin-4-yl)piperazine → HCID 69642368, compound

HRID 1794182Notes

Reaction equation

HRID 1794182 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:14])[C:7]=1[N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1.Cl.[CH3:16][O:17][C:18]1[C:26]2[O:25][C:24](C)(C)C[C:22]=2[C:21]([C:29]2[C@@H:38]3[C@@H:33]([CH2:34][CH:35]=[CH:36][CH2:37]3)[C:32](=[O:39])[N:31]([C:40]3[CH:45]=[CH:44][C:43]([C:46](N4CCN(C/C=C/C5C=CC=CC=5)CC4)=[O:47])=[CH:42][CH:41]=3)[N:30]=2)=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:14])[C:7]=1[N:8]1[CH2:13][CH2:12][N:11]([C:46]([C:43]2[CH:44]=[CH:45][C:40]([N:31]3[N:30]=[C:29]([C:21]4[CH:20]=[CH:19][C:18]([O:17][CH3:16])=[C:26]([O:25][CH3:24])[CH:22]=4)[C@@H:38]4[C@@H:33]([CH2:34][CH:35]=[CH:36][CH2:37]4)[C:32]3=[O:39])=[CH:41][CH:42]=2)=[O:47])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazineHCID 69642098HCID 69642098, compound

Product 1

HCID 69642368HCID 69642368, compound

Procedure

Prepared from intermediate product A6 and 1-(3,5-Dichloropyridin-4-yl)piperazine as described for compound 8. Crystallised as the free base from methanol. M.p. 137–139° C.

Workup

  1. customCrystallised as the free base from methanol

Sources & evidence

ORD record
ord-7f2c841004d2460fb4fc89455ec6239d
Source dataset
uspto-grants-2006_04
Patent number
US07022696B2

Reaction notes

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