HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 10025434, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloromethyl-2-methyl-2H-[1,2,3]triazole | HCID 22220910 | — |
| Reactant | HCID 22220927 | HCID 22220927 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 10025434 | HCID 10025434 | — |
Reaction Steps
3-(5-Methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindol-8-ol (35 mg) and potassium carbonate (30 mg) and 5-(chloromethyl)-2-methyltriazole were heated together with DMF (1 ml) at 120° C. for 2 hours. The reaction was diluted with water and extracted with ethyl acetate. The organic layer was washed with water (×5), dried and evaporated to yield an oil which was purified by column chromatography on silica using methanol/dichloromethane to yield the title compound (7.8 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07022724B2 |
| Source dataset | uspto-grants-2006_04 |
| ORD ID | ord-2915b8405f504e80929c582a49a82fd7 |
| Source note | uspto-grants-2006_04 |