Potassium Phosphate, Tribasic → HCID 69896255, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole (100 mg) (prepared as in Example 4), methylboronic acid (72 mg), K3PO4 (276 mg), and dioxane (5 ml) was degassed with a stream of N2 for 0.5 h. tetrakis(triphenylphosphine) palladium(0) (20 mg) was added and the reaction heated to 80° C. for 1 h. The reaction mixture was cooled, poured into H2O and extracted into CH2Cl2, dried (MgSO4), and concentrated under reduced pressure to give the title compound (56 mg, 57%). 1H NMR (400 MHz, CDCl3) δ 7.82 (1H, s), 8.54–7.52 (2H, m), 7.47–7.37 (3H, m), 7.21 (1H, dd, J=7.8, 0.7 Hz), 7.14 (1H, d, J=8.0 Hz), 3.98 (2H, s), 2.70 (3H, s), 2.45 (3H, s), m/z (ES+) 329 (M+H)+.

Provenance & Evidence