2-Pyridinemethanamine → HCID 69587996, compound

Participants

Reaction Steps

8-Bromo-3-(5-chloro-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole (50 mg, 0.12 mmol) (prepared in Example 39), sodium acetate (30 mg) and 2-(aminomethyl)pyridine (13 mg) in 5 ml methanol were heated to reflux for 18 h. The reaction was cooled, concentrated and partitioned between H2O—CH2Cl2. The organic phase and extracts were combined, dried over (MgSO4) and concentrated. The residue was purified by preparative TLC using 3% MeOH—CH2Cl2 as eluent. Trituration with 1PrOH gave the title compound as a beige solid (11 mg). 1H NMR (400 MHz, d6-DMSO) δ 8.53–8.54 (1H, m), 8.38–8.40 (1H, m), 8.1 (1H, s), 7.75–7.8 (1H, m), 7.65–7.68 (1H, m), 7.55–7.60 (2H, m), 7.38–7.5 (4H, m), 7.28–7.30 (2H, m), 4.68–4.7 (2H, m), 4.45 (2H, s). m/z (ES+) 485/487 (M+H)+.

Provenance & Evidence