Thionyl Chloride → HCID 22221311, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-phenylphenyl)-4-isoxazolylmethanol (4.16 g) and thionyl chloride (10.0 ml) was stirred at 0° C. for 30 min. The reaction mixture was concentrated, and saturated aqueous sodium hydrogencarbonate was added to the residue. The mixture was extracted with ethyl acetate and the ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The obtained colorless crystals were filtrated to give 4-chloromethyl-3-(4-phenylphenyl)isoxazole (3.84 g, yield 92%). The crystals were recrystallized from ethyl acetate-hexane. melting point: 102–103° C.

Provenance & Evidence