Water → HCID 22221077, compound

Participants

Reaction Steps

To a solution of 3-[5-(4-methylthiophenyl)-4-isoxazolyl]propan-1-ol (500 mg) in tetrahydrofuran (30 ml) was gradually added m-chloroperbenzoic acid (870 mg) at 0° C., and the mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into iced water, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography to give crystals (480 mg, yield 85%) of 3-[5-(4-methylsulfonylphenyl)-4-isoxazolyl]propan-1-ol from a fraction eluted with acetone-hexane (1:1, volume ratio). The crystals were recrystallized from ethyl acetate-isopropyl ether to give a colorless needle. melting point: 125–126° C.

Provenance & Evidence