Bromotrimethylsilane → HCID 86591388, compound

Participants

Reaction Steps

A mixture of N-[4-(diethylphosphonomethyl)phenyl]-3-(5-phenyl-4-isoxazolyl)propionamide (221 mg), trimethylsilyl bromide (0.17 ml) and acetonitrile (10 ml) was stirred at room temperature for 16 hr. The reaction mixture was purified by preparative HPLC to give N-[4-(ethylphosphonomethyl)phenyl]-3-(5-phenyl-4-isoxazolyl)propionamide (139 mg, 67%). melting point: 80–82° C.

Provenance & Evidence