5-Methoxy-2-(4-methoxy-phenyl)-7-propyl-benzofuran → 2-(4-Hydroxy-phenyl)-7-propyl-benzofuran-5-ol

Participants

Role	Name	HCID	Charge
Reactant	5-Methoxy-2-(4-methoxy-phenyl)-7-propyl-benzofuran	HCID 10214897	—
Reactant	Pyr-HCl	HCID 67725173	—
Product	2-(4-Hydroxy-phenyl)-7-propyl-benzofuran-5-ol	HCID 10149301	—

Reaction Steps

Compound 35 was prepared via demethylation of 34 with Pyr-HCl: Mp=178–180° C.; 1H NMR (DMSO-d6) δ 9.81 (br s, 1 H), 9.02 (br s, 1 H), 7.67 (d, 2 H, J=8.5 Hz), 6.98 (s, 1 H), 6.87 (d, 2 H, J=8.5 Hz), 6.71 (d, 1 H, J=2.1 Hz), 6.51 (d, 1 H, J=2.1 Hz), 2.84 (t, 2 H, J=7.8 Hz), 1.75 (q, 2 H, J=7.4 Hz), 0.96 (t, 3 H, J=7.4 Hz); MS 269 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07022733B2
Source dataset	uspto-grants-2006_04
ORD ID	ord-ac739cf436fc43dfb2eab80da8ef35b6
Source note	uspto-grants-2006_04