HCID 10193055, compound → HCID 10236495, compound

Participants

Reaction Conditions

Reaction Steps

The 2-Iodo-4-methoxy-6-nitro-phenol 97 (1 g, 2.25 mmol based on 0.67 molar purity) in DMF/pyrrolidine (3 mL/3 mL) was treated with 4-methoxystyryne (0.45 g, 3.4 mmol), catalytic PdCl2(PPh3)2 and catalytic Cul was heated at 60° C. until reaction was adjudged complete by TLC analysis (<1 h to completion). The reaction was worked up by partitioning between EtOAc and 2 N HCl aq. The EtOAc was washed with saturated NaHCO3 aq, brine and dried over MgSO4. After filtering and concentrating, the product was purified by trituration with MeOH to give 0.57 g: Mp=141° C.

Provenance & Evidence