Pyridinium chloride → HCID 22221618, compound

Participants

Reaction Steps

A mixture of 122 (0.37 g, 1.3 mmol) and Pyridine HCl (10 g).was heated. to 200° C. After 1 hr, the reaction was cooled, diluted with water and extracted with EtOAc. The EtOAc layer was dried over MgSO4, concentrated and the product was purified by column chromatography (50% Et OActHex) to give 123 as a solid (0.25 g, 74%): Mp=274–276° C., 1H NMR (DMSO-6) δ 9.96 (br s, 1 H), 9.52 (br s, 1 H), 7.74 (d, 2 H, J=8.4 Hz), 7.17–7.16 (m, 3 H), 6.89 (d, 2 H, J=8.4 Hz),2.64 (s, 3 H); MS 267 (M−H)−

Provenance & Evidence