Pyridinium chloride → HCID 22221635, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 140 (50 mg, 0.15 mmol) and Pyridine HCl (3 g) was heated to 200° C. After 1 hr, the reaction was cooled, diluted with water and extracted with EtOAc. The EtOAc was dried over MgSO4, concentrated to give a solid which was triturated with CH2Cl2 and filtered to give 141 (30 mg, 65%): Mp=210–213° C.; 1H NMR (DMSO-d6) δ 9.86 (s, 1 H), 9.28 (s, 1 H), 7.71 (d, 2 H, J=8.8 Hz), 7.05 (s, 1 H), 6.89–6.86 (m, 3 H), 6.69 (d, 1 H), 2.0 Hz), 3.91–3.84 (m, 2 H); MS 307 [M−H]−

Provenance & Evidence