tert-butyl N-(pyrrolidin-3-yl)carbamate → tert-butyl N-[1-[5-[(3-iodo-4-methylphenyl)carbamoyl]-2-pyridinyl]pyrrolidin-3-yl]carbamate

HRID 179457Notes

Reaction equation

HRID 179457 reaction equation
[C:19]([NH:20][CH:21]1[CH2:22][CH2:23][NH:24][CH2:25]1)([O:26][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:31].[C:32]([CH3:33])([CH3:34])([CH3:35])[O:36][C:37](=[O:38])[N:39]1[CH2:40][CH2:41][N:42]([c:45]2[n:46][cH:47][c:48]([C:51]([NH:52][c:53]3[cH:54][c:55]([I:60])[c:56]([CH3:59])[cH:57][cH:58]3)=[O:61])[cH:49][cH:50]2)[CH2:43][CH2:44]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:6]([NH:7][c:8]2[cH:9][cH:10][c:11]([CH3:12])[c:13]([I:14])[cH:15]2)=[O:16])[cH:17][n:18]1>>[C:32]([CH3:33])([CH3:34])([CH3:35])[O:36][C:37](=[O:38])[NH:39][CH:40]1[CH2:41][N:42]([c:45]2[n:46][cH:47][c:48]([C:51]([NH:52][c:53]3[cH:54][c:55]([I:60])[c:56]([CH3:59])[cH:57][cH:58]3)=[O:61])[cH:49][cH:50]2)[CH2:43][CH2:44]1

Participants

4

Reactant 3

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 79255626-chloro-N-(3-iodo-4-methyl-phenyl)-nicotinamideHCID 593181844-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 67377315tert-butyl N-[1-[5-[(3-iodo-4-methylphenyl)carbamoyl]-2-pyridinyl]pyrrolidin-3-yl]carbamate

Sources & evidence

ORD record
ord-50314f5efe8f46d282427e41c8e0048a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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