反应详情

2-Ethoxy-N-(4-methyl-2-propylimidazol-1-yl)benzamide from Example D (50 g, 174 mmol) is introduced into acetic acid. Bromine (12.5 ml, 243.6 mmol) dissolved in acetic acid is added dropwise at room temperature. The mixture is then stirred at room temperature until conversion is complete (up to 3 hours). For working up, water and ethanol (or optionally acetone) are added to the mixture. The product is precipitated by neutralizing with sodium hydroxide solution. The crystals are isolated, washed and dried in vacuo.

1. additionis added dropwise at room temperature
2. custom(up to 3 hours)
3. customThe product is precipitated by neutralizing with sodium hydroxide solution
4. customThe crystals are isolated
5. washwashed
6. customdried in vacuo