反应详情

A solution of the compound of Example 1 Step 5 (50 mg, 0.11 mmol) in CHCl3 (10 mL) was treated with 4-toluoyl chloride (16.9 mg, 0.11 mmol) followed by Et3N (11.1 mg, 0.11 mmol). The resulting mixture was stirred at room temperature for 18 h, then concentrated under vacuum. The crude product was purified by preparative reverse-phase HPLC on a YMC S5 ODS 30×100 mm column to afford the desired product as a yellow glass (60 mg, 95%); LC/MS 100% at 4.32 min (ESI): 574 (M+H)+.

1. concentrationconcentrated under vacuum
2. customThe crude product was purified by preparative reverse-phase HPLC on a YMC S5 ODS 30×100 mm column