Bromine → HCID 22222345, compound

Participants

Reaction Steps

A mixture of 31 (430 mg, 1.44 mmol), bromine (345 mg, 2.16 mmol) and NaOAc (236 mg, 2.88 mmol) in acetic acid (10 mL) was heated at 40–45° C. for 14 h. The reaction mixture was poured into ice water, a yellow solid was collected by filtration. The crude product 32 was used in the next step without further purification. 1H-NMR (400 MHz, CDCl3): δ 7.06–7.31 (m, 5H), 6.13 (d, J=16.41 Hz, 1H), 4.80 (d, J=16.41 Hz, 1H), 4.56 (t, J=7.26 Hz, 1H), 2.77 (s, 3H), 2.33 (m, 1H), 2.13 (m, 1H), 0.67 (t, J=7.27 Hz, 3H).

Provenance & Evidence