Acetic Acid → 4(1H)-Quinazolinone

Participants

Reaction Conditions

Reaction Steps

A solution of 2,4-dichloro-6,7-dimethoxy-quinazoline (2.12 g, 8.20 mmol) in 1 M NaOH (50 mL) and THF (15 mL) was stirred at room temperature under an argon blanket for 23 hours. The solution was cooled to 0° C., then acidified to pH 5 with AcOH. The resulting solids were collected by vacuum filtration and dried in a vacuum oven at 70° C. overnight to provide Intermediate 8 as a pale yellow powder (2.02 g, 100%). 1H NMR (300 MHz, DMSO-d6) δ: 7.38 (s, 1H), 7.08 (s, 1H), 3.88 (s, 3H), 3.85 (s, 3H), 3.50–3.20 (br s, 1H).

Provenance & Evidence