Trifluoroacetic acid → HCID 10207991, compound

Participants

Reaction Steps

A19 was prepared in an manner analogous to example A1 with the exception that in step A1.1 4-aminosulfonylbenzylamine hydrochloride was substituted for 4-methylsulfonylbenzylamine hydrochloride, and in step A1.2, 6-aminoquinoline was substituted for ethyl 2-amino-4-methyl-5-thiazole carboxylate. The product was purified by preparatory reverse phase HPLC to yield A19. Analytical HPLC ret. time=1.09 min, [M+H]+=517.12. HPLC conditions: phenomenex primesphere 5 u C18 4.6×30 mm column, 5 mL/min, 2 min gradient, at 254 nm 0–100% B in A(A; 0.1% TFA in 90/10 water/methanol; B; 0.1% TFA in 10/90 water/methanol)

Provenance & Evidence