Trifluoroacetic acid → HCID 10164813, compound

Participants

Reaction Steps

A20 was prepared in an manner analogous to example A1 with the exception that in step A1.1 4-aminosulfonylbenzylamine hydrochloride was substituted for 4-methylsulfonylbenzylamine hydrochloride, and in step A1.2, 7-aminoquinazoline (prepared according to the literature procedure of Naff, et. al. J. Am. Chem. Soc. 1951, 73, 1372–1373.) was substituted for ethyl 2-amino-4-methyl-5-thiazole carboxylate. The product was purified by preparatory reverse phase HPLC to yield A20. Analytical HPLC ret. time=2.17 min, [M+H]+=518.30. HPLC conditions: YMC ODS 5 μ, 5 mL/min, 4 min gradient, at 254 nm 0–100% B in A(A; 0.1% TFA in 90/10 water/methanol; B; 0.1% TFA in 10/90 water/methanol)

Provenance & Evidence