Hydrochloric Acid → Sertraline Hydrochloride

Participants

Reaction Conditions

Reaction Steps

Sertraline base (3 g) was stirred with 35 mL water. The slurry was heated at −70° C. and, while maintaining this temperature, concentrated hydrochloric acid was added until pH 1 was reached. During acidification, almost complete dissolution was observed followed by precipitation. The mixture was cooled to room temperature and stirred for 2 hours. The solid was isolated by filtration, washed with water and dried overnight at 50–60° C., yielding 3.23 g (96%) sertraline hydrochloride Form V.

Provenance & Evidence