1,4-Dioxa-8-azaspiro(4.5)decane → 4-(1,4-Dioxa-8-aza-spiro[4.5]dec-8-yl)-3-fluoro-benzaldehyde

Participants

Reaction Steps

The title compound was prepared from, 1,4 dioxa-8-azaspiro[4.5]decane and 3,4-difluorobenzaldehyde according to the procedure of Example 56 as an orange oil; 1H NMR (300 MHz, CDCl3) δ 1.88 (t, J=5.7 Hz, 4H), 3.35 (t, J=5.8 Hz, 4H), 4.01 (s, 4H), 6.96 (t, J=7.8 Hz, 1H), 7.47–7.49 (m, 1H), 7.53–7.58 (m, 1H), 9.81 (s, 1H); MS (ES) m/z: 265.8 (MH+).

Provenance & Evidence