N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamide → HCID 69655031, compound

Participants

Reaction Steps

The title compound was prepared from 5-[4-(4-oxo-piperidin-1-yl)-benzyl]-imidazolidine-2,4-dione (which was obtained in Example 44) and N-[5-(2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 9) according to the procedure of Example 73 as a pale yellowish solid; mp>105° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.80–2.00 (m, 2 H), 2.50–2.75 (m, 5 H), 2.86 (d, J=4.8 Hz, 2 H), 2.93 (s, 3 H), 3.50–3.65 (m, 2 H), 4.24 (t, J=4.8 Hz, 1 H), 4.51 (dd, J=8.2, 4.0 Hz, 1 H), 6.81 (d, J=6.3 Hz, 1 H), 6.84 (d, J=5.7 Hz, 2 H), 7.18 (d, J=1.8 Hz, 1 H), 7.85 (brs, 1 H); MS (ES) m/z: 518.0 (MH+); HRMS Calcd. for C24H32N5O6S (MH+): 518.2073. Found: 518.2056.

Provenance & Evidence