N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamide → HCID 145832529, compound

Participants

Reaction Steps

The title compound was prepared from 1-[4-(2-imino-4-oxo-thiazolidin-5-ylidenemethyl)-phenyl]-piperidin-4-one (which was obtained in Example 43) and N-[5-(2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide (which was obtained in Example 9) according to the procedure of Example 73 as a pale yellowish solid; mp>210° C. (decomposed); 1H NMR (300 MHz, DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.80–2.00 (m, 2 H), 2.50–3.00 (m, 5 H), 2.92 (s, 3 H), 3.70–3.90 (m, 2 H), 4.47 (dd, J=7.9, 4.4 Hz, 1 H), 6.81 (d,J=8.3 Hz, 1 H), 6.90–7.10 (m, 3 H), 7.18 (d, J=2.0 Hz, 2 H), 7.39 (d, J=8.9 Hz, 2 H), 7.47 (s, 1 H); MS (ES) m/z: 532.0 (MH+); HRMS Calcd. for C24H30N5O5S2 (MH+): 532.1688. Found: 532.1672.

Provenance & Evidence